Synthesis of chiral mono(N-heterocyclic carbene) palladium and gold complexes with a 1,1'-biphenyl scaffold and their applications in catalysis

• Lian-jun Liu,
• Feijun Wang,
• Wenfeng Wang,
• Mei-xin Zhao and
• Min Shi

Beilstein J. Org. Chem. 2011, 7, 555–564, doi:10.3762/bjoc.7.64

• showed good catalytic activities in the asymmetric intramolecular hydroamination reaction to give the corresponding product in moderate ee. Keywords: chiral mono(N-heterocyclic carbene) complex; Heck–Mizoroki reaction; hydroamination; Suzuki–Miyaura reaction; Introduction N-heterocyclic carbene (NHC

• –Mizoroki reaction catalyzed by NHC–Pd(II) complex 7a. NHC–Au complex (S)-6a catalyzed asymmetric intramolecular hydroamination. Supporting Information Supporting Information File 158: Experimental procedures and characterization data of compounds given in this article. Supporting Information File 159

• (II) complex. Synthesis of mono(NHC)–Au(I) complex. Synthesis of mono(NHC)–Au(I) complex (S)-6b. Synthesis of mono(NHC)–Au(I) complex (S)-6c. The application of catalysts (S)-6b and 6c in the intramolecular hydroamination reaction. Suzuki–Miyaura reaction catalyzed by NHC–Pd(II) complex 7a. Heck

Polyionic polymers – heterogeneous media for metal nanoparticles as catalyst in Suzuki–Miyaura and Heck–Mizoroki reactions under flow conditions

• Klaas Mennecke and
• Andreas Kirschning

Beilstein J. Org. Chem. 2009, 5, No. 21, doi:10.3762/bjoc.5.21

• heterogeneous supports for palladium(0) nanoparticles is described. These functionalized polymers were incorporated inside a flow reactor and employed in Suzuki–Miyaura and Heck cross couplings under continuous flow conditions. Keywords: Heck–Mizoroki reaction; heterogeneous catalysis; ion exchange resin

• industrial relevance is the Heck–Mizoroki reaction. We were able to perform C-C coupling reaction under flow conditions with aryl iodides 23–28 using catalyst 3 (Table 2). Optimization of the conditions for our monolithic flow reactor was conducted with 4′-iodoacetophenone (23) and styrene (29) as coupling

• substrates under these standard conditions. This observation has been noted in many examples of heterogenized palladium salts or complexes [34]. Likewise, these species are commonly not reactive enough to promote the Heck–Mizoroki reaction with aryl bromides. It should be noted that under supercritical or